Maternal and Offspring Outcomes in Pregnant Women With Pre-existing Atherosclerotic Cardiovascular Disease: A Nationwide Mother-Child Cohort Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cardiovascular Diseases
- Sponsor
- Samsung Medical Center
- Enrollment
- 5461222
- Locations
- 1
- Primary Endpoint
- Occurence of post-partum MACCE
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
A growing body of evidence supports associations between cardiovascular health and adverse pregnancy outcome and between adverse pregnancy outcome and atherosclerotic cardiovascular disease and builds on the well-established pathways known to exist between cardiovascular health and atherosclerotic cardiovascular disease across the life course and intergenerationally. Furthermore, previous studies frequently lack comprehensive long-term follow-up, making it difficult to assess the enduring impacts of maternal cardiovascular health on postpartum outcomes and long-term maternal and child health.
Detailed Description
the current study aimed to evaluate the associations between maternal pre-existent atherosclerotic cardiovascular disease and adverse pregnancy outcomes, and the combined effect of maternal pre-existent atherosclerotic cardiovascular disease and adverse pregnancy outcomes on the risk of long-term adverse events of offspring.
Investigators
Ki Hong Choi
Associate Professor
Samsung Medical Center
Eligibility Criteria
Inclusion Criteria
- •Women with live birth from Korea (between January 1, 2005 to December 31, 2019)
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Occurence of post-partum MACCE
Time Frame: up to 5 years
major adverse cardiac and cerebrovascular event
Secondary Outcomes
- Occurence of All-cause death(up to 5 years)
- Occurence of revascularization(up to 5 years)
- Occurence of stroke(up to 5 years)
- Occurence of neonatal adverse events in offspring(within 30 days)
- Occurence of adverse infant events in offspring(Within 1 year)
- Occurence of myocardial infarction(up to 5 years)
- Occurence of adverse pregnancy outcome(At delivery)
- Occurence of major congenital malformation in offspring(At delivery)
- Occurence of neurodevelopmental disorders(up to 5 years)