Maternal and Offspring Outcomes in Pregnant Women With Pre-existing Atherosclerotic Cardiovascular Disease: A Nationwide Mother-Child Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 5,461,222
- 试验地点
- 1
- 主要终点
- Occurence of post-partum MACCE
研究概览
简要总结
A growing body of evidence supports associations between cardiovascular health and adverse pregnancy outcome and between adverse pregnancy outcome and atherosclerotic cardiovascular disease and builds on the well-established pathways known to exist between cardiovascular health and atherosclerotic cardiovascular disease across the life course and intergenerationally. Furthermore, previous studies frequently lack comprehensive long-term follow-up, making it difficult to assess the enduring impacts of maternal cardiovascular health on postpartum outcomes and long-term maternal and child health.
详细描述
the current study aimed to evaluate the associations between maternal pre-existent atherosclerotic cardiovascular disease and adverse pregnancy outcomes, and the combined effect of maternal pre-existent atherosclerotic cardiovascular disease and adverse pregnancy outcomes on the risk of long-term adverse events of offspring.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women with live birth from Korea (between January 1, 2005 to December 31, 2019)
排除标准
- 未提供
结局指标
主要结局
Occurence of post-partum MACCE
时间窗: up to 5 years
major adverse cardiac and cerebrovascular event
次要结局
- Occurence of All-cause death(up to 5 years)
- Occurence of revascularization(up to 5 years)
- Occurence of stroke(up to 5 years)
- Occurence of neonatal adverse events in offspring(within 30 days)
- Occurence of adverse infant events in offspring(Within 1 year)
- Occurence of myocardial infarction(up to 5 years)
- Occurence of adverse pregnancy outcome(At delivery)
- Occurence of major congenital malformation in offspring(At delivery)
- Occurence of neurodevelopmental disorders(up to 5 years)
研究者
Ki Hong Choi
Associate Professor
Samsung Medical Center