Conjugate Pneumococcal Vaccine in Ataxia Telangiectasia (AT)

Phase 3

Completed

• Conditions: Ataxia Telangiectasia (AT)

• Registration Number: NCT00656409
• Lead Sponsor: Institute of Child Health

Brief Summary

Ataxia Telangiectasia (AT) is an autosomal recessive inherited condition caused by mutations in the ATM gene1. Patients suffer from neuro-degenerative problems, usually commencing in the second year of life, and affecting predominantly the cerebellum. They also develop the characteristic superficial telangiectases. Between 60 and 80% of affected children are immunodeficient. This is associated with deficiency of immunoglobulin A (IgA ) 2, of IgG23 and of antibody responses to pneumococcal polysaccharides4. Patients suffer recurrent sino-pulmonary infections but a recent study suggests poor correlation between immune status and immunological parameters5. If uncontrolled, recurrent pulmonary infections can contribute to the development of chronic lung disease and bronchiectasis. Preventative management includes continuous prophylactic antibiotic treatment in some with the need for replacement immunoglobulin therapy in only a small proportion of cases. Antibiotics have been reasonably effective in this situation but the emergence of resistance amongst community acquired pneumococcal isolates is a cause for concern. Appropriate immunisation strategies may also have a role.

This study is designed to look at antibody responses in a one versus two dose regimen in a cohort of AT patients recruited through the AT Society a national charitable organisation involved in providing support to families with this condition and in fostering education and research in the field.

Detailed Description

Not available

Study Timeline

• Study Start: 2006-06
• Study Completion: 2008-03
• Status Verified: 2008-04
• Study First Submitted: 2008-04-07
• Study First Submitted QC: 2008-04-10
• Last Update Submitted: 2008-04-10
• Study First Posted: 2008-04-11
• Last Update Posted: 2008-04-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Genetically confirmed diagnosis of AT

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Immunogenicity of vaccine

Secondary Outcome Measures

Name	Time	Method
Incidence of adverse reactions to vaccine

Trial Locations

Locations (1)

Great Ormond Street Hospital; 🇬🇧 London, United Kingdom