Investigating the Potential of Novel Dementia Biomarkers - an MRI, fNIRS and EEG Study
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Alzheimer Disease, Early Onset
- Sponsor
- German Center for Neurodegenerative Diseases (DZNE)
- Enrollment
- 100
- Primary Endpoint
- Performance on verbal fluency test
- Last Updated
- 5 years ago
Overview
Brief Summary
The study will investigate structural and functional characteristics of the brain of dementia patients compared to healthy controls in order to get a better insight into importance of early biomarkers for the diagnosis of Alzheimer's dementia. The methods for obtaining biomarkers incude magnetic resonance imaging (MRI), near-infrared spectroscopy (fNIRS) and electroencephalography (EEG), electrocardiography (ECG) and neurophyshological assessments. Special parameters are being studied that have already been shown to detect changes in the early stages of Alzheimer's dementia.
Investigators
Notger Müller
Professor Dr. Notger Müller
German Center for Neurodegenerative Diseases (DZNE)
Eligibility Criteria
Inclusion Criteria
- •Clinically diagnosed MCI patients and matched healthy controls
Exclusion Criteria
- •Metal in body and tatoos;
- •Other chronic systemic neurological, cardiologic, metabolic or musculo-skeletal diseases which have been proven to influence the outcome variables
- •Alcohol abuse
- •Colour blindness
- •Pregnancy
- •Surgery in the last 6 months
- •Uncorrected vision
Outcomes
Primary Outcomes
Performance on verbal fluency test
Time Frame: 10 minutes
Test of verbal fluency, more words spoken means a better score
Heart Rate Variability (HRV)
Time Frame: 1 hour
ECG-based variability measures in R-R intervals, both in rest abd during tasks
Locus Coeruleus (LC) Intensity
Time Frame: 15 minutes
LC-intensity can be assesed with specific MRI sequences (TSE MRI-Sequence (see Dordevic et al, 2017))
Error-rate on Stroop-test
Time Frame: 10 minutes
Test of executive functions, higher error-rate means worse performance
Event-related-potential (ERP) waveforms: negative deflections (N100, N300) and positive deflections (P100, P300)
Time Frame: 1 hour
Voltages generated in the brain structures in response to specific events (Event-related potentials (ERPs))
Volume of brain regions
Time Frame: 30 minutes
VBM (voxel-based morphometry)
fNIRS-based change in oxyhemoglobin and deoxyhemoglobin
Time Frame: 1 hour
In response to each task there is a hemodynamic response, which can be measured by fNIRS. In particular, fNIRS measures changes in blood oxy- and deoxy-hemoglobin.
Score on CERAD-Plus
Time Frame: 30 minutes
Cognitive performance measure in points, with a higher score meaning better performance
Error-rate on N-Back-test
Time Frame: 10 minutes
Working memory test, higher error-rate means worse performance