Endothelial Dysfunction and Coronary Artery Spasm
- Conditions
- Coronary Vasospasm
- Registration Number
- NCT00619294
- Lead Sponsor
- Kumamoto University
- Brief Summary
Non-obstructive coronary artery disease (NOCAD) frequently accounts for myocardial ischemia in women. Endothelial dysfunction is a pathogenic factor in coronary spastic angina (CSA). CSA is an important cause of NOCAD diagnosed invasively by coronary angiography (CAG). Digital reactive hyperemia peripheral arterial tonometry (RH-PAT) provides noninvasive evaluation of endothelial dysfunction. The investigators hypothesized that the fingertip RH-PAT could predict the presence of CSA in women.
- Detailed Description
Outline of methods:
RH-PAT was measured in women with chest pain prior to CAG. Coronary spasm was diagnosed by intra-coronary acetylcholine (ACh) provocation test. Using Flow-Wire, we assessed coronary endothelial function by coronary blood flow increase in response to ACh (ACh-CBF) and coronary flow reserve was assessed by adenosine (Ad-CFR).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 158
- Stable post-menopausal women complaining angina-like chest pain
- Severe valvular disease
- Hypertrophic cardiomyopathy
- Severe peripheral artery disease
- Uncontrolled hypertension
- Severe collagen diseases
- Acute coronary syndrome
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Ischemic heart disease diagnosed by cardiac catheterization From Aug 2006 to May 2009
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Kumamoto University Hospital
🇯🇵Kumamoto, Japan