Digital Tonometry for Measurement of Peripheral Artery Reactive Hyperemia as Non-invasive Test for Diagnosis of Coronary Artery Spasm
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 158
- 试验地点
- 1
- 主要终点
- Ischemic heart disease diagnosed by cardiac catheterization
研究概览
简要总结
Non-obstructive coronary artery disease (NOCAD) frequently accounts for myocardial ischemia in women. Endothelial dysfunction is a pathogenic factor in coronary spastic angina (CSA). CSA is an important cause of NOCAD diagnosed invasively by coronary angiography (CAG). Digital reactive hyperemia peripheral arterial tonometry (RH-PAT) provides noninvasive evaluation of endothelial dysfunction. The investigators hypothesized that the fingertip RH-PAT could predict the presence of CSA in women.
详细描述
Outline of methods:
RH-PAT was measured in women with chest pain prior to CAG. Coronary spasm was diagnosed by intra-coronary acetylcholine (ACh) provocation test. Using Flow-Wire, we assessed coronary endothelial function by coronary blood flow increase in response to ACh (ACh-CBF) and coronary flow reserve was assessed by adenosine (Ad-CFR).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 90 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Stable post-menopausal women complaining angina-like chest pain
排除标准
- •Severe valvular disease
- •Hypertrophic cardiomyopathy
- •Severe peripheral artery disease
- •Uncontrolled hypertension
- •Severe collagen diseases
- •Acute coronary syndrome
结局指标
主要结局
Ischemic heart disease diagnosed by cardiac catheterization
时间窗: From Aug 2006 to May 2009
次要结局
未报告次要终点
研究者
Seigo Sugiyama
MD, PhD
Kumamoto University