The Influence of Apolipoprotein C3 Variants on Liver Steatosis and Serum Liver Enzyme Values in Obese Children
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- genotype distribution of APOC3 rs2854117 and rs2854116 polymorphisms in subjects with and without liver steatosis
研究概览
简要总结
In the past decades, obesity in children is much more prevalent in the world. Given the increasing prevalence of pediatric obesity worldwide, fatty liver incidence is on the rise.
Genetic variant in apolipoprotein C3 (APOC3) gene is associated with increased liver fat content in adults.
The aim of this study is to find out whether APOC3 single nucleotide polymorphism (SNP) influence fatty liver in obese children and adolescent.
详细描述
The primary aim of this study is to assess the associations between to investigate the association of rs2854117 C > T and rs2854116 T > C SNPs of the APOC3 gene with liver steatosis, as measured by liver ultrasound.
As a secondary aim, the investigators will examine the associations between APOC3 rs2854117 C > T and rs2854116 T > C SNPs and serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. In addition, the investigators will further analyze the association with other biomarkers, such as body mass index, adiponectin and insulin resistance.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 6 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 6-18 years old
- •Obesity definition: BMI > 95% according to the age- and gender-specific standard suggested by National Health Institute in Taiwan
- •Willing to give written informed consent by parents
排除标准
- •Alcohol consumption
- •Chronic liver diseases, including hepatitis B, hepatitis C, Wilson disease and autoimmune hepatitis
- •Major systemic diseases, including cardiopulmonary disease, renal failure, cancer, and psychotic disorder
结局指标
主要结局
genotype distribution of APOC3 rs2854117 and rs2854116 polymorphisms in subjects with and without liver steatosis
时间窗: Oct 2013 ~ Dec 2014
次要结局
- genotype distribution of APOC3 rs2854117 and rs2854116 polymorphisms in subjects with and without insulin resistance(Oct 2013 ~ Dec 2014)