NL-OMON34394招募中不适用
HEALTH-2007-2.4.5-10: Understanding and combating age related muscle weakness *MYOAGE* - MYOAGE
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 265
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •patients undergoing either total knee replacement or knee periarticular reconstruction (fracture repair, corrective osteotomy, capsular ligament reconstruction) that provide for an open surgery in the lateral part of distal femur; or total/partial hip replacement or proximal femur osteosynthesis.
- •healthy young: age ranges 18-30 years;
- •elderly: age 70-80 years, free living, ADL independent
排除标准
- •PHASE 1:;Exclusion:
- •patients less than 20 years
- •patients that underwent previous open surgery in parts concerned the biopsy collection
- •patients with rheumatoid diseases (RA, polymyositis, dermatomyositis etc)
- •patients that undergo insulin therapy
- •patients with haemocoagulative syndromes in which collection could cause strong bleeding
- •patients with serious neuromuscular disease (flabby and spastic paralysis of legs, myasthenia, myodystrophia
- •patients with serious hepatorenal failure
- •patients with serious infectious disease and active malignant neoplasia
- •patients with serious psychiatric disorders, chronic abuse of alcohol and drugs
- •patients that use steroidal medicines
- •patients unable to give a personal consent
- •Participating in other ongoing research projects.;PHASE 2:
- •Participating in other ongoing research projects.
- •patients unable to give a personal consent
- •walking distance 250m and less;
- •MMSE 23 and lower;
- •GDS 5 and higher;
- •institutionalized;
- •comorbidity: neurological disorders (stroke, M. Parkinson, dementia, muscle disease), metabolic diseases (insuline dependent DM), arthritis: rheumatoid arthritis, severe (pain and functional limitation) osteoarthritis (hip and knee), cancer: diagnosis and treatment of cancer within the last year, polymyalgia rheumatic, heart failure (NYHA 3-4), COPD (Gold 3-4), chronic pain syndrome (fibromyalgia, complex regional pain syndrome etc); haemocoagulative syndromes in which biopsy could cause strong bleeding.
- •medication: immunosuppressive drugs (e.g. prednisone, methotrexat, biologicals (TNF-alpha antagonists etc)), insulin, anticoagulantia, e.g. coumarines, carbaspirin calcium.
- •fracture last year;
- •hip and knee replacement in medical history last 2 years;
- •hip and knee replacement causing pain and physical limitation;
- •amputation;
- •immobilization for 1 week during the last 3 months;
- •sports on a highly competitive level
- •severe hearing impairment.
- •severe visual impairment ..
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