NL-OMON24566招募中不适用

The pharmacokinetic effect of clarithromycin on the AUC0-12h of linezolid in multidrug-resistant and extensively drug-resistant tuberculosis patients.

niversity Medical Center GroningenA.t.t.n. Prof Dr JGW Kosterink, Department of Hospital and Clinical PharmacyP.O. Box 30.001; 9700 RB Groningen,The NetherlandsTel: +31 50 361 4071Fax: +31 50 361 4087Email: j.g.w.kosterink@umcg.nl0 个研究点目标入组 7 人开始时间: 待定最近更新: 2024年6月11日

研究概览

简要总结

Bolhuis MS, Van Altena R, Uges DR, van der Werf TS, Kosterink JG, Alffenaar JW. Clarithromycin significantly increases linezolid serum concentrations. Antimicrob Agents Chemother 2010.

研究设计

研究类型: Interventional

入排标准

入选标准

•1. Age ≥ 18 years old;
•2. Signed informed consent;

排除标准

•1. Hypersensitivity to linezolid, clarithromycin, erythromycin, or any macrolide antibiotics, or any of the excipients of linezolid or clarithromycin;
•2. Concomitant use with astemizole, cisapride, ergotamine derivatives
•(dihydroergotamine, ergotamine), monoamine oxidase inhibitors (phenelzine,
•isocarboxazid, selegiline, or moclobemide), pimozide, or terfenadine;

研究者

发起方

niversity Medical Center GroningenA.t.t.n. Prof Dr JGW Kosterink, Department of Hospital and Clinical PharmacyP.O. Box 30.001; 9700 RB Groningen,The NetherlandsTel: +31 50 361 4071Fax: +31 50 361 4087Email: j.g.w.kosterink@umcg.nl

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