Identification of Correlates of Protection Against Shigella and Enterotoxigenic Escherichia Coli Infections
试验速览
- 阶段
- 不适用
- 入组人数
- 330
- 试验地点
- 7
- 主要终点
- Identification of cases of shigellosis and ETEC-associated diarrhea
研究概览
简要总结
The aim of this study is to accelerate the development of vaccine candidates against diarrheal diseases caused by Shigella and Enterotoxigenic Escherichia coli (ETEC). We plan to identify cases of laboratory-proven shigellosis and ETEC-associated diarrhea, to study humoral and cellular immune parameters following natural infections with Shigella and ETEC, and to compare the level of pre-existing local, humoral and cellular immune parameters in cases of shigellosis and ETEC-associated diarrhea and in matched controls.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- — 至 65 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Lab-confirmed Shigella or ETEC
- •Individuals or patients without diarrheal disease
排除标准
- 未提供
研究组 & 干预措施
Diarrheal disease
干预措施: Laboratory Tests (Other)
Control
Samples of stool, blood, urine saliva
干预措施: Laboratory Tests (Other)
结局指标
主要结局
Identification of cases of shigellosis and ETEC-associated diarrhea
时间窗: Four years
Stool of patients examined in laboratory and identified as infected with the pathogens
次要结局
未报告次要终点