An observational study on the microcirculation in healthy childre
- Conditions
- 10019280not applicable
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 65
In order to be eligible to participate in this study, a subject must meet all of the following criteria:
For group (A):
- Healthy children from the age of 0 until 7 years old;
- Undergoing non-cardiac elective surgery;
- Mechanical ventilation through an endotracheal tube;
- Parental informed consent. ;For group (B):
- Healthy children from the age of 6 until 18 years old;
- Informed consent:
o Parental informed consent for all children from the age of 6 until 16 years old;
o Informed co-consent of children from the age of 12 until 16 years old;
o Informed consent of children from the age of 16 until 18 years old.
A potential subject who meets any of the following criteria will be excluded from participation in this study:
For group (A):
- Absence of parental informed consent;
- Preterm new born (adjusted age * 36 weeks);
- Cardiovascular, renal or oncological disease;
- Mechanical or spontaneous ventilation through a larynx mask airway.;For group (B):
- Absence of (parental) informed consent;
- Cardiovascular, renal or oncological disease;
- Use of drugs;
- Smoking;
- Pregnancy.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>With incident dark field illumination (IDF) imaging, a video-microscopy<br /><br>technique that allows the direct visualization of the sublingual<br /><br>microcirculation, variables of vessel density (total vessel density (TVD) and<br /><br>perfused vessel density (PVD)), two indexes of vascular perfusion<br /><br>(microvascular flow index (MFI) and proportion of perfused vessels (PPV)) and a<br /><br>heterogeneity index of the flow (heterogeneity index (HI)) will be collected.<br /><br>Demographic data and medical history will also be assessed before measurements.<br /><br></p><br>
- Secondary Outcome Measures
Name Time Method <p>Not applicable.</p><br>