Exercise-induced alterations in diurnal rates of muscle protein synthesis in young me

Completed

Conditions: muscle growth
Muscle protein synthesis
10028302

Registration Number: NL-OMON42768

Lead Sponsor: niversiteit Maastricht

Brief Summary: Trial is onging in other countries

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 12

Inclusion Criteria

* Healthy males
* Age between 18 and 35 y
* BMI between 18.5 and 30 kg/m2
* Moderate level of physical activity (exercising 2-4 hours per week)

Exclusion Criteria

* Celiac disease
* Lactose intolerance
* Smoking
* Diabetes
* Cancer
* Cardiovascular Disease
* Donated blood within the last 3 months
* Diagnosed GI tract diseases
* Arthritic conditions
* A history of neuromuscular problems
* Any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>From p18 of C1 protocol document:<br /><br><br /><br>The main study endpoints are muscle protein synthesis (MPS) rates. In order to<br /><br>determine the MPS, the following parameters will be measured:<br /><br><br /><br>* Muscle protein-bound L-[2,3,3,3-2H4]-alanine enrichment (expressed as MPE)<br /><br>* Plasma free L-[2,3,3,3-2H4]-alanine enrichment (expressed as MPE)<br /><br>* Saliva 2H2O enrichment (Expressed as APE)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>From p18 of C1 protocol document:<br /><br><br /><br>Secondary endpoints include:<br /><br>* Total plasma amino acids (AAmax [mol/L])<br /><br> Plasma alanine concentrations (expressed as *mol/L)</p><br>