Comparison of Intensive Care Unit Stay and Relapse Among Diabetic Ketoacidosis Patients Maintained Basal Bolus Insulin Administration in Combination With Continuous Intravenous Insulin Infusion VS Non Maintaining Basal Insulin Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Resolution of diabetic ketoacidosis
研究概览
简要总结
This study aimed to assess intensive care unit stay and relapse among patients of Diabetic ketoacidosis (type 1 diabetes mellitus) maintained basal bolus insulin and patients non maintaining along with intervenors insulin infusion.
详细描述
Diabetic ketoacidosis is one of the common, potentially serious, and avoidable acute complications of diabetes mellitus. Diabetic ketoacidosis is caused by a decrease in effective circulating insulin associated with elevations in counter-regulatory hormones . This potentially life-threatening complication of type 1.
diabetes mellitus is frequently mismanaged, leading to morbidity and increased length of stay. Advances in near-patient testing technology have improved patient care, by facilitating rapid diagnosis and closer monitoring of treatment response.
Diabetic ketoacidosis most often occurs in people with type 1 diabetes, but can also occur in patients with poorly controlled type 2 diabetes under stressful conditions .
Management of Diabetic ketoacidosis requires reversing metabolic derangements by correcting volume depletion and electrolyte imbalances and administering insulin to correct acidosis while concurrently treating the precipitating illness .
Diabetic ketoacidosis is traditionally managed using intravenous regular insulin infusion in intensive care unit /high dependency unit.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 21 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients aged 21y or more
- •who are known to have type 1 diabetes on known basal bolus insulin regimen - presented with diabetic ketoacidosis.
排除标准
- •Patients with type 2 diabetes mellitus.
- •If hemodynamically unstable patients.
- •Patients with other metabolic problems (hepatic coma, renal failure, disturbed conscious level .
研究组 & 干预措施
Group I
Patients treated with insulin infusion without basal insulin.
干预措施: insulin infusion without basal insulin (Drug)
Group II
Patients treated with insulin infusion with basal insulin.
干预措施: insulin infusion with basal insulin (Drug)
Group III
Patients treated with insulin infusion with basal insulin and bolus.
干预措施: Insulin infusion with basal insulin and bolus (Drug)
结局指标
主要结局
Resolution of diabetic ketoacidosis
时间窗: 4 days
Criteria of resolution of Diabetic Ketoacidosis The anion gap (AG) \<12 mEq/L. Venous pH \>7.3. Serum bicarbonate ≥15 mEq/L
次要结局
- Random blood sugar assessment(every 2 hours till 4 days)
研究者
Marwa Hashem Mahrous Saad
Resident
Tanta University