Evaluating the effect of a probiotic supplement including Lactobacillus and Bifidiobacterium (with emphasis on the strains of Lactobacillus acidophilus LA14 and NCFM, Lactobacillus gasseri and Bifidiobacterium lactis BI07) on 24 hour urine oxalate and calcium oxalate supersaturation in recurrent calcium stone patients with hyperoxaluria: a randomized clinical trial

ational Institute for Medical Research Developement0 个研究点目标入组 110 人开始时间: 待定最近更新: 2018年2月22日

适应症

试验速览

暂无简介。

•Patients with a history of at least 2 times of calcium (radiopaque) kidney stone episodes in recent 25 months (Recurrent stone former); at least 20 days since the last treatment they have; at least 3 months since following general dietary advice on recurrence prevention (drinking advice, high oxalate food restriction, animal protein restriction, fruit and vegetable intake encouragement, salt restriction and fat intake modification); age 18 to 65 years; Hyperoxaluria (24-hour urine oxalate over 40 and less than 80 mg); willingness to cooperate in the study.
•Exclusion criteria:
•Primary or enteric hyperoxaluria (urine oxalate>80 mg/24h); Taking any drugs which affects calcium metabolism, including thiazides; Taking any drugs which affects oxalate metabolism or calcium oxalate supersaturation, including vitamin B6; History of diabetes mellitus, hepatic failure, thyroid or parathyroid diseases, chronic kiodney disease (CKD), Urinary tract infection (UTI), chronic diarrhea or immunologic diseases; Pregnancy or lactation

发起方

ational Institute for Medical Research Developement