Associations between the initial concentration of serum TNF alpha and effects due to increasing a dose of Infliximab, and between effects of infliximab and the concentration of serum IL-6
Not Applicable
- Conditions
- Rheumatoid Arthritis
- Registration Number
- JPRN-UMIN000009887
- Lead Sponsor
- Department of Orthopaedic surgery, Tohoku University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Not provided
Exclusion Criteria
1. Patients with severe infectious disease 2. Patients with active tuberculosis 3. Patients with allergy to infliximab or mouse protein 4. Patients with demyelinated disease 5. Patients with congestive heart failure
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Disease Activity Score-28 (DAS28-CRP/ESR) Simplified Disease Activity Index (SDAI) Clinical Disease Activity Index (CDAI)
- Secondary Outcome Measures
Name Time Method Van der Heijde' modified Sharp score