The Therapeutic Effect of Dysthyroid Optic Neuropathy
- Conditions
- Thyroid Eye Disease
- Registration Number
- NCT04096612
- Lead Sponsor
- Sun Yat-sen University
- Brief Summary
Thyroid associated ophthalmopathy (TAO) is a common autoimmune disorder. The pathogenesis of TAO is unclear, and studies found that T cell, B cell and monocytes, macrophages and mast cells are located in the orbital tissue of TAO. Dysthyroid optic neuropathy (DON) is the most serious complication of TAO, which can cause blurred vision, color vision and vision function damage, and affects the quality of life. Investigation of the therapeutic effect of orbital decompression may provide some clues to make the policy at treatment of DON. We explore the therapeutic effect of orbital decompression in patients with DON in both eyes.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 20
- Ability to perform visual fields and VEP examination Without any serious systemic diseases Without any surgery on eyes in six months
- With any serious systemic diseases With any surgery on eyes in six months
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method proptosis 6 months proptosis in mm
upper eyelid retraction 6 months upper eyelid retraction in mm
CAS 6 months clinical activity score
BCVA 6 months best corrected visual acuity in logMAR
IOP 6 months intraocular pressure in mmHg
- Secondary Outcome Measures
Name Time Method MD 6 months mean deviation of visual field in dB
PSD 6 months pattern standard deviation of visual field in dB
Trial Locations
- Locations (1)
Zhongshan Opthalmic Center
🇨🇳Guangdong, Guangdong, China
Zhongshan Opthalmic Center🇨🇳Guangdong, Guangdong, ChinaHuasheng Yang, M.D.Contact+8620-87331539yanghs64@126.com