Cardiac dysfunction and undiagnosed heart failure in women as a long term effect of the treatment of breast cancer in an unselected primary care setting

Completed

• Conditions: cardiac dysfunction; heart failure; 10082206; 10018865

• Registration Number: NL-OMON39592
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 700

Inclusion Criteria

Patients
- Women with breast cancer who were treated with chemotherapy and/or radiotherapy in 2006 or before (minimal follow-up period of five years) and after 1970 (due to old fashion treatment or incomplete data)
- Written informed consent
Controls
- Female patients without a history breast cancer, registered in the general practice of the case-patient, matched on age
- Written informed consent

Exclusion Criteria

Patients and controls
- Patients over 80 years of age at the time of diagnosis (because of an expected high frequency of CVD and a life expectancy of less than 10 years in this age-group)
- Any history of other cancer (possibility of chemotherapy and / or radiotherapy)
- Any history of receiving chemotherapy for other indications
- Women who are unable to participate (e.g. terminally or mentally ill)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome of this study is the proportion of women with a systolic<br /><br>and / or diastolic cardiac dysfunction at echocardiography.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary outcome is heart failure: a combination of clinical complaints<br /><br>and objective abnormalities at physical examination, laboratory examination or<br /><br>echocardiography.</p><br>