Brain Mapping by Integrated Neurotechnologies for Disease Studies: Human Brain Aging Imaging Study
Not Applicable
- Conditions
- Mild cognitive impairment, preclinical AD
- Registration Number
- JPRN-UMIN000017505
- Lead Sponsor
- The University of Tokyo Hospital Unit for Early and Exploratory Clinical Development
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
Not provided
Exclusion Criteria
No past history of major depression or bipolar disorder, schizophrenia, alcoholism or drug addiction. CT or MRI findings indicative of cerebrovascular disease or ischemic changes that are causative for cognitive disorders. Individuals who are continuously taking drugs affecting cognitive functions. Individuals with unstable disease states that may hamper continuation of the study Individuals who are participating in other clinical study including CDR, WMS-R, logical memory or MMSE upon enrollment
Study & Design
- Study Type
- Interventional,observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Volumetric differences in the hippocampus and other areas in cognitive normal and MCI Micro volumetric analysis of subregions of hippocampus and other medial temporal areas in cognitive normal and MCI Differences in cerebral blood flow using ASL in cognitive normal and MCI Differences in functional connectivity using rsfMRI in cognitive normal and MCI Differences in DTI parameters in cognitive normal and MCI Differences in brain volume in hippocampal and other areas in amyloid positive and negative individuals Differences in volume of subregions of hippocampus and other medial temporal areas in amyloid positive and negative individuals Differences in ASL and rsfMRI parameters in amyloid positive and negative individuals Differences in DTI parameters in amyloid positive and negative individuals
- Secondary Outcome Measures
Name Time Method