Effect of colostrum on immune function after intense strenuous exercise in well-trained cyclists.

Completed

• Conditions: common cold; upper respiratory tract infection (URTI); 10027665; 10019815

• Registration Number: NL-OMON32615
• Lead Sponsor: Wageningen Universiteit

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

- Male cyclists/triathletes with at least 2 years of cycling experience.
- Cycling at least 3 times a week during peak season.
- 18 - 35 years old.
- Body mass index (BMI) 20 - 25 kg/m2.

Exclusion Criteria

- Known symptoms of milk allergy.
- Known symptoms of immune disease.
- Symptoms of infections during the last month before the start of the experiment.
- Smoking.
- Use of more than 2 alcoholic consumptions per day during the last 2 weeks before the start of the experiment and during the experiment itself.
- Use of drugs.
- Use of colostrum during the last month before the start of the experiment.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The immune function will be assessed by measuring changes in several markers,<br /><br>i.e. salivary IgA level, plasma immunoglobulins and cytokines, number of<br /><br>lymphocytes, neutrophils and natural killer cells and plasma cortisol<br /><br>concentration. In addition, in vitro cell proliferation, cytokine production<br /><br>and apoptosis in peripheral blood mononuclear cells (PBMCs) will be measured. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Changes in circulating metabolites and endocannabinoids serve as secundary<br /><br>study parameters.</p><br>