Channel Detection to Predict Ventricular Arrhythmia in Patients With Non-ischemic Cardiomyopathy
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Non-ischemic Cardiomyopathy
- Sponsor
- Hospices Civils de Lyon
- Enrollment
- 30
- Primary Endpoint
- Detect pro arrhythmogenic scar characteristics
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Sudden cardiac death (SCD) risk stratification is a challenge in non-ischemic cardiomyopathy (NICM). The underlying mechanism of monomorphic ventricular tachycardia (VT) is mostly scar related. While electrophysiological mechanisms underlying ventricular arrhythmia are well known, late gadolinium enhanced (LGE) cardiac MRI-3D reconstructions are now able to guide VT ablation procedures. Such exam may help in identifying specific properties of scar at risk of malignant arrhythmia.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Adult with NICM
- •Previous history of ventricular tachycardia (VT) and no previous history of VT
Exclusion Criteria
- •Inherited cardiomyopathies
- •Previous history of myocarditis WITHOUT oedema/scar at the MRI
Outcomes
Primary Outcomes
Detect pro arrhythmogenic scar characteristics
Time Frame: baseline : collected at the time of the cardiac MRI
The outcomes will aim to provide scar characteristics from 3D cardiac MRI reconstructions to detect pro arrhythmic properties in NICM patients. Comparisons between NICM patients who experienced VT ablation and NICM patients without history of ventricular arrhythmia will be made. In both groups, Primary outcome will aim to measure the number of the conducting channels into scars (n).