NCT00162461Unknown不适用
The Use of Phenytoin Metabolic Ratio as a Putative Marker of CYP2C9 Activity In-vivo
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 入组人数
- 1,200
- 试验地点
- 1
- 主要终点
- Correlation between phenytoin metabolic ratio and CYP2C9 genotype
研究概览
简要总结
The use of phenytoin metabolism to produce S-HPPH accounts for more than 85% of its metabolism. This metabolic pathway is mediated by the activity of CYP2C9.
The purpose of the present study is:
- To confirm the use of phenytoin metabolic ratio as a marker of CYP2C9 activity
- To correlate phenytoin metabolic ratio with CYP2C9 genotype
- To study the frequency distribution of CYP2C9 activity in-vivo
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age range of 20-50 years old
- •Absence of significant disease states
排除标准
- •The presence of significant disease states
- •The use of drugs (including birth control pills)
研究组 & 干预措施
Phenytoin
Experimental
干预措施: Phenytoin single dose (300 mg) (Drug)
结局指标
主要结局
Correlation between phenytoin metabolic ratio and CYP2C9 genotype
时间窗: 24 hours
Frequency distribution of phenytoin metabolic ratio in the population
时间窗: 24 hours
次要结局
未报告次要终点
研究者
研究点 (1)
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