Cardiac Biopsy Collection Repository and Database
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 400
- 试验地点
- 2
- 主要终点
- Discover and quantify the concentration of novel diagnostic and prognostic biomarkers
研究概览
简要总结
Use samples procured from patients to improve understanding of molecular, cellular, and tissue-level processes produced by a variety of cardiac diseases and therapeutic interventions.
详细描述
This is a prospective study enrolling patients referred for or undergoing cardiovascular procedures or treatment at the University of Kentucky. The study aims to facilitate the discovery of novel diagnostic biomarkers and therapeutic targets and improve the pathophysiological understanding of cardiac conditions.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients undergoing evaluation of a cardiac condition or receiving a right heart catheterization with biopsy clinically indicated who are at least 18 years of age.
排除标准
- •Patients without a cardiovascular or amyloidosis diagnosis, under 18 years of age.
研究组 & 干预措施
Biological specimens
Biological specimens taken from cardiovascular procedures
结局指标
主要结局
Discover and quantify the concentration of novel diagnostic and prognostic biomarkers
时间窗: 12/21/2021-12/31/2030
Use biospecimens procured from patients with cardiac conditions to identify diagnostic surrogate biomarkers using discovery proteomics. In Cardiac Amyloidosis, the serum levels will be compared between confirmed ATTR and non-ATTR heart failure patients and a diagnostic threshold will be established. The research aims to advance understanding of cardiac diseases and to support the development of improved therapies.
次要结局
未报告次要终点
研究者
Kenneth S. Campbell
Associate Professor
University of Kentucky