Characterization of the Microbiome in Peritoneum, Jejunum, Rectum and Stool
- Conditions
- Chronic PancreatitisObesityFatty Liver, NonalcoholicDiabetes MellitusLeaky Gut Syndrome
- Interventions
- Diagnostic Test: Microbial Swab
- Registration Number
- NCT04067440
- Lead Sponsor
- University Hospital, Saarland
- Brief Summary
Characterization of the human microbiome in the jejunum and comparison to the microbiome in the rectum and stool in order to see how the microbial communities change within the intestines.
- Detailed Description
Subjects to undergo surgery with opening of the jejunum will be sampled with sterile swabs from peritoneum and the inside of the jejunum. A swab will also be taken from the rectum.
The peritoneum is regarded as a sterile place until today. We try to either verify this, we also could find a scientific base for theories like leaky gut or other forms of bacterial migration through the intestinal wall.
Many of these patients undergo bariatric surgery. Many of them do have a dramatic change in glucose metabolism immediate after surgery. Therefore stool swabs will be taken before and 5 days after surgery.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 30
- abdominal surgery containing opening of jejunum
- singing of consent
- inflammative condition (appendicitis, pancreatitis, Crohn, Colitis ulcerous, cholecystitis and similar)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Patients Microbial Swab Subjects to undergo surgery including opening of the jejunum with non-inflammative condition.
- Primary Outcome Measures
Name Time Method Characterization of microbiome intra-operative Previously uncharacterized sites: jejunum, peritoneum
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland,
🇩🇪Homburg/Saar, Germany