A Cross-Sectional study to explore the correlation between PET SUVR and amyloid-beta plaques in the retina, identified by fluorescence imaging using the EidonTM (RetiaTM) retinal imaging system with and without curcumin labeling.

euroVision Imaging LLC0 sites286 target enrollmentDecember 6, 2016

Overview

No summary available.

Registry

who.int

Start Date

December 6, 2016

End Date

August 13, 2019

Last Updated

5 years ago

Study Type

Interventional

Sex

All

Sponsor

euroVision Imaging LLC

•1\. Enrolled in the AIBL study with a A Ddiagnosis of MCI, or healthy controls within 36 months as per the AIBL criteria at the screening visit .
•2\. PET amyloid brain scan within 36 months of baseline visit
•3\.Participant must be able to provide written informed consent in English.
•4\. Male or Female age 60 years or older at the screening visit
•5\. In the opinion of the retinal photographer, clear ocular media and pupillary dilation to allow for ocular imaging

•1\.The participant has advanced retinal disease, advanced cataracts or other advanced ocular conditions that in the opinion of the investigator are likely to affect obtaining clear images of the retina.
•2\. Participant has had prior ocular surgery within 2 months of planned retinal imaging, or is still taking post\-operative ocular medications at first day of retinal imaging.
•3\. Participants with known current gallstone.
•4\. Participants who have undergone angioplasty in the last 3 months.
•5Participants who have had major surgery within 4 weeks of trial inclusion or planned surgical procedure during the trial period.
•6\. Significant haemorrhagic event (in past 12 months) or cardiovascular disease ( ie, history of myocardial infarction within past 6 months of trial inclusion, congestive cardiac failure NYHA grade II ).
•7\.Participant with retinitis pigmentosa.
•8\. Participants with current bile duct obstruction (participants who have undergone a cholecystectomy will be considered eligible).
•9\. Participants with significant uncontrolled gastrointestinal disorders (including stomach ulcers and uncontrolled hyperacidity disorders) which in the opinion of the investigator will be aggravated by the intake of curcumin.
•10\. Participants with known allergy to Tropicamide eye drops, Vitamin E or turmeric.