To evaluate the clinical and microbiological effects of probiotic Lactobacillus reuteri chewable tablets in the treatment of chronic periodontitis patients, as an adjunct to conventional periodontal therapy
Not Applicable
Completed
- Registration Number
- CTRI/2019/03/018148
- Lead Sponsor
- nique Biotech
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 34
Inclusion Criteria
1.Presence of at least 16 remaining teeth with a minimum of four teeth in each quadrant.
2.Mild to moderate chronic periodontitis as defined by the AAP classification 1999.
3.Presence of at least one teeth with probing the pocket depth of 4 - 6 mm in the oral cavity.
4.Systemically healthy patients
Exclusion Criteria
1.Known drug allergies or Infectious Disease.
2.Periodontal treatment or antibiotic therapy in the preceding six months prior to initial examination.
3.History of Smoking/Alcohol consumption.
4.Pregnant and/or Lactating
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.Probing pocket depth <br/ ><br>2.Microbiological counts of P. gingivalis and L. reuteri <br/ ><br>Timepoint: Baseline, 1 month and 3 Months
- Secondary Outcome Measures
Name Time Method 1.Clinical Attachment Level <br/ ><br>2.Gingival Index (Loe and Silness 1963) <br/ ><br>3.Plaque index (Silness and Loe1964) <br/ ><br>Timepoint: Baseline, 1 month and 3 Months