Improved Chest CT Diagnostic and Contrast Medium Administration

Not Applicable

Completed

• Conditions: Pulmonary Disease
• Interventions: Other: Adopted contrast media amount by using different approaches

• Registration Number: NCT05645796
• Lead Sponsor: Oslo Metropolitan University

Brief Summary

Investigation of impact of using different CM approaches on contrast enhancement in chest Ct examinations - A prospective study

Detailed Description

Continuing advances in computed tomography (CT) in the past decades such as short scanning times with multi-detector CT (MDCT) requires contrast medium (CM) administration to be precisely planned to ensure a diagnostically accurate CT scans. To improve the chest CT diagnostic, the contrast enhancement in the thoracic vessels shoulde be increased.

The most important patient-related factors affecting the magnitude of vascular and parenchymal contrast enhancement are body weight. Historical practice has been to use a fixed volume of CM independent of body weight. Research has shown a clear relationship between vessel enhancement and patient weight, and that fixed CM volume technique is inappropriate, as smaller patients may receive excessive volume, and larger patients insufficient volume resulting in reduced image quality and poor diagnostic. In addition, excess CM can result in contrast induced adverse effects and nephropathy. To overcome these problems, it is essential to adjust the CM volume to the patient's total body weight and body composition. This adjustment can be done in different ways. The aim of this study is to identify which weight/body tailored CM administration is the best replacement for fixed CM administration in chest CT. The cost and procedure time will also be explored.

Study Timeline

• Study Start: 2021-08-02
• Study First Submitted: 2022-11-28
• Status Verified: 2022-12
• Study First Submitted QC: 2022-12-07
• Study First Posted: 2022-12-12
• Primary Completion: 2023-01-15
• Study Completion: 2023-01-15
• Last Update Submitted: 2023-03-27
• Last Update Posted: 2023-03-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 360

Inclusion Criteria

• patients undergoing chest CT examination between August 2019 and September 2021
• age > 18 years

Exclusion Criteria

• hemodynamic instability
• cardiac failure
• pacemaker
• renal insufficiency (estimated glomerular filtration rate <30 mL/min/1.73 m2)
• contraindications to contrast enhanced CT
• age < 18 years

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Fixed group	Adopted contrast media amount by using different approaches	They received a fixed amount of contrast media prior to CT scan
body composition tailored group	Adopted contrast media amount by using different approaches	They received a body tailored amount of contrast media prior to CT scan

Primary Outcome Measures

Name	Time	Method
Contrast medium protocols in routine chest CT - A survey study	15 months	survey of what kind of contrast medium approaches are used in European hospitals

Trial Locations

Locations (1)

OsloMet University; 🇳🇴 Oslo, Norway