Hong Kong Cohort of Abnormal Sleep in Ageing Population (HK-ASAP): an Observational Study on Brain Health and Sleep Quality in Community-dwelling Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 238
- 试验地点
- 1
- 主要终点
- Sleep quality will be measured by the Pittsburgh Sleep Quality Index (PSQI)
研究概览
简要总结
Poor sleep quality can significantly jeopardize the brain health, cognitive functions, daily activities, quality of life, and even be implicated as a key potential contributing factor in the development of accelerated cognitive decline and prodromal dementia. Consequently, research efforts to understand, and therefore potentially model, the effects of sleep quality on cognition and brain health are of great pragmatic values.
详细描述
Objectives: This study aims to investigate the cognitive changes in older adults with sleep disturbances, examine the neuroimaging contributors to poor sleep quality and cognitive deficits.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 55 Years 至 95 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Chinese old adults are the ones who are over 60 years of chronological age.
- •Sleep disturbance: individual's subjective sleep quality is assessed using the Pittsburgh Sleep Quality Index (PSQI) with a total score >5.
排除标准
- •History of bipolar disorders or psychosis.
- •History of major neurological deficits, including stroke, transient ischemic attack or brain tumor.
- •Unable to participant magnetic resonance imaging (MRI) scanning.
结局指标
主要结局
Sleep quality will be measured by the Pittsburgh Sleep Quality Index (PSQI)
时间窗: Baseline
Pittsburgh Sleep Quality Index (PSQI) is a validated 19-item self-reported questionnaire
Global cognition will be measured by the Montreal Cognitive Assessment Hong Kong version (HK MoCA)
时间窗: Baseline
The Montreal Cognitive Assessment Hong Kong version (HK MoCA) is a validated and widely used screening assessment for detecting cognitive impairment, which measures an array of cognitive functions such as visuospatial, memory, language and attention.
Complex attention will be measured by the Attention Network Test (ANT)
时间窗: Baseline
The ANT paradigm, as a computerized test, was used and performed by E-Prime 3.0.
次要结局
- The levels of Aβ40 and Aβ42 will be measured by saliva analysis(Baseline)
- Executive functions will be measured by the category verbal fluency test (CVFT)(Baseline)
- Memory and learning will be measured by the Word list learning test (WLLT)(Baseline)
研究者
LU Hanna
Assistant Professor
Chinese University of Hong Kong