Hong Kong Cohort of Abnormal Sleep in Ageing Population (HK-ASAP): Focusing on Brain Health and Sleep Quality

Recruiting

• Conditions: Cognitive Decline; Brain Disease; Sleep Disturbance; Aging

• Registration Number: NCT06170073
• Lead Sponsor: Chinese University of Hong Kong

Brief Summary

Poor sleep quality can significantly jeopardize the brain health, cognitive functions, daily activities, quality of life, and even be implicated as a key potential contributing factor in the development of accelerated cognitive decline and prodromal dementia. Consequently, research efforts to understand, and therefore potentially model, the effects of sleep quality on cognition and brain health are of great pragmatic values.

Detailed Description

Objectives: This study aims to investigate the cognitive changes in older adults with sleep disturbances, examine the neuroimaging contributors to poor sleep quality and cognitive deficits.

Study Timeline

• Study Start: 2023-10-01
• Status Verified: 2023-12
• Study First Submitted: 2023-12-06
• Study First Submitted QC: 2023-12-06
• Last Update Submitted: 2023-12-06
• Study First Posted: 2023-12-14
• Last Update Posted: 2023-12-14
• Primary Completion: 2024-12-31
• Study Completion: 2025-03-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 244

Inclusion Criteria

• Chinese old adults are the ones who are over 60 years of chronological age.
• Sleep disturbance: individual's subjective sleep quality is assessed using the Pittsburgh Sleep Quality Index (PSQI) with a total score >5.

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Exclusion Criteria

• History of bipolar disorders or psychosis.
• History of major neurological deficits, including stroke, transient ischemic attack or brain tumor.
• Unable to participant magnetic resonance imaging (MRI) scanning.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Sleep quality will be measured by the Pittsburgh Sleep Quality Index (PSQI)	Baseline	Pittsburgh Sleep Quality Index (PSQI) is a validated 19-item self-reported questionnaire
Global cognition will be measured by the Montreal Cognitive Assessment Hong Kong version (HK MoCA)	Baseline	The Montreal Cognitive Assessment Hong Kong version (HK MoCA) is a validated and widely used screening assessment for detecting cognitive impairment, which measures an array of cognitive functions such as visuospatial, memory, language and attention.
Complex attention will be measured by the Attention Network Test (ANT)	Baseline	The ANT paradigm, as a computerized test, was used and performed by E-Prime 3.0.

Secondary Outcome Measures

Name	Time	Method
The levels of Aβ40 and Aβ42 will be measured by saliva analysis	Baseline	saliva samples will be collected at a consistent time of day to avoid circadian effects and will be kept on ice during the collection.
Executive functions will be measured by the category verbal fluency test (CVFT)	Baseline	On each trial of CVFT, the participants will be asked to overtly generate words in the animal category, fruit category and vegetable category as many as possible within 60 seconds
Memory and learning will be measured by the Word list learning test (WLLT)	Baseline	Word list learning test (WLLT), consisting of fifteen semantically non-associated words that is presented consecutively over three free trials of immediate recall, a 20-min delayed recall and followed by yes/no recognition.

Trial Locations

Locations (1)

The Chinese University of Hong Kong; 🇭🇰 Hong Kong, Tai Po, Hong Kong