Effects of Transcranial Direct Current Stimulation in Individuals With Schizophrenia
- Conditions
- Schizophrenia
- Interventions
- Procedure: transcranial direct current stimulation
- Registration Number
- NCT01607840
- Lead Sponsor
- Johns Hopkins University
- Brief Summary
This research is being done to determine whether transcranial direct current stimulation (tDCS) can improve certain mental abilities and alter functional connectivity in individuals with Schizophrenia. In this research, a 9 volt battery is used to deliver very weak electrical current to the surface of the scalp while participants complete cognitive tasks. Participants also receive a brain scan before and after stimulation. Our aim is to determine if tDCS can improve mental abilities in individuals with schizophrenia.
- Detailed Description
Participants enrolled into this study may be asked to do the following:
Grant permission for the researchers to view medical records associated with their language/cognitive difficulties
Complete a questionnaire, provide a health history, and take some pencil-and-paper tests of problem-solving and memory in order to verify eligibility to participate and to able to safely undergo the experimental procedures.
Complete several tasks (e.g., saying words out loud, naming objects, drawing designs, remembering lists of words, searching for images or letters, and/or completing puzzles) based upon a number of cognitive functions such as language, memory, vision, processing, and perception.
Wear electrodes that will be placed on the scalp with a large rubberized band. These electrodes will administer very weak electrical current (tDCS) from a 9 volt battery for 20 to 60 minutes.
Participation in several study conditions. The exact conditions and their order will be randomized. Under some conditions, participants may receive active stimulation (tDCS) and under other conditions, they may receive sham stimulation.
The experimental sessions will last approximately 2 hours and participants may be asked to have more than one testing session in a day or to return for additional sessions.
Have a Magnetic Resonance Imaging (MRI) brain scan.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 11
- Diagnosis of Schizophrenia
- English as a native language
- appreciable deficits in hearing or vision
- appreciable accent
- any implanted metal device or pacemaker
- Dementia or Mini Mental Exam below 24
- History of Seizures
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Anodal Stimulation transcranial direct current stimulation transcranial direct current stimulation using Anodal stimulation over the area of interest Cathodal transcranial direct current stimulation transcranial direct current stimulation using cathodal stimulation over the brain area of interest Sham Stimulation transcranial direct current stimulation transcranial direct current stimulation that is ramped up and ramped down providing the sensation of tDCS without actually delivering tDCS
- Primary Outcome Measures
Name Time Method Cognitive Test Performance The average time frame is approximately 2 hours Cognitive test performance by subjects will be evaluated upon completion of enrollment to determine if tDCS improved performance on cognitive tests.
- Secondary Outcome Measures
Name Time Method Functional Connectivity Changes Associated with tDCS Time frame is approximately 2 hours Pre- and post- stimulation MRI's will be conducted to determine if tDCS is associated with changes in neural activity.
Trial Locations
- Locations (1)
Department of Neurology
🇺🇸Baltimore, Maryland, United States