A Study of the Association Between Tobacco Smoking and Bipolar Affective Disorder

Completed

• Conditions: Bipolar Disorder

• Registration Number: NCT00741299
• Lead Sponsor: Tirat Carmel Mental Health Center

Brief Summary

The purpose of this study is to examine whether tobacco smoking is associated with bipolar affective disorder (severity of depressive and manic symptoms, presence of psychotic symptoms, history of a suicide attempts and other clinical features.)

Detailed Description

An association exists between smoking and schizophrenia, independent of other factors and related to psychotic symptomatology. Only a few small descriptive studies have examined the prevalence and correlates of tobacco use among bipolar patients with conflicting results. Patients who smoke score higher on rating scales for psychotic symptoms than their non-smoking peers. While the association of smoking with psychotic symptomatology in schizophrenia is established, such association according to bipolar affective disorder has been reported in a few studies and remains unclear. Also a few studies reported about association of smoking with depressive and manic symptoms, and with suicidal behavior in bipolar patients. Thus further investigation of these issues is warranted.

Study Timeline

• Study Start: 2007-08
• Study First Submitted: 2008-08-25
• Study First Submitted QC: 2008-08-25
• Study First Posted: 2008-08-26
• Primary Completion: 2009-07
• Study Completion: 2009-09
• Status Verified: 2012-07
• Last Update Submitted: 2012-07-25
• Last Update Posted: 2012-07-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Age 18-65 male or female
• DSM -IV criteria for bipolar I affective disorder
• Ability and willingness to sign informed consent for participation in the study

Exclusion Criteria

• Unwillingness or inability to participate in the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Relationship between smoking and other factors including: bipolar subtype, current and past clinical status, illness severity,history of a suicide attempts, age of bipolar onset, gender, education, social class, economic status.	One interview session

Trial Locations

Locations (1)

Tirat Carmel Mental Health Center; 🇮🇱 Tirat HaCarmel, Israel