跳至主要内容
临床试验/CTRI/2026/03/106580
CTRI/2026/03/106580尚未招募不适用

Determining the association between pre-operative frailty and nutritional status with the occurrence of emergence delirium in pediatric patients under general anesthesia

Dr. Puneet Khanna1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2026年3月30日

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
100
试验地点
1

研究概览

简要总结

This investigation is to examine the complex interplay of malnutrition, frailty, and their impact on paediatric health outcomes [1]. Recognizing the severity of malnutrition, prestigious organizations such as the European Society for Clinical Nutrition and metabolism at Risk (ESPEN) and the European Society for Gastroenterology, Hepatology, and Nutrition (ESPGHAN) recommendfor screening at admission [2-4]. This proactive method aims to identify nutritionally at-risk children, enabling for the development of personalized nutritional support treatment plans. The study focuses to the complex interaction between malnutrition and sarcopenia, as well as body habitus abnormalities such sarcopenic obesity (SO) in children. Studies across diverse clinical populations in adults have shown the increased risks associated with SO, emphasizing the limitations of using BMI as a sole nutritional indicator. Frailty assessments and risk stratification, particularly preoperatively, have been recognized as crucial tools for effective patient care planning and critical care resource utilization. study expands to the prevalence of emergence delirium (ED) and postoperative cognitive dysfunction (POCD) in pediatric anesthesia as Current data suggests that the occurrence of ED varies widely, ranging from 20% to 80% of all pediatric anesthesia cases, though the majority of literature suggests a prevalence closer to 20% It is essential, however, to extend our focus to children, whose developing brains may also be susceptible to ED.

In conclusion, this comprehensive strategy aims to improve the understanding of the synergistic effects of malnutrition and frailty on development delirium in pediatric health care. By shedding light on potential interventions and strategies, the study aims to improve patient outcomes, reduce complications, and increase overall well-being for pediatric patients facing a variety of medical difficulties. The multidimensional approach deals with essential aspects of pediatric health, emphasizing the value of proactive measurements, detailed evaluations, and individualized interventions for the best patient care

[1] Mehta N.M., Corkins M.R., Lyman B., Malone A., Goday P.S., Carney L.N., MonczkaJ.L., Plogsted S.W., Schwenk W.F. Definingpediatric malnutrition: A paradigm shift toward etiology-related definitions. JPEN J. Parenter. Enteral Nutr. 2013;37:460–481.doi: 10.1177/014860711347997

[2] Agostoni C., Axelson I., Colomb V., Goulet O., Koletzko B., Michaelsen K.F., Puntis J.W., Rigo J., Shamir R., Szajewska H., etal. ESPGHAN Committee on Nutrition; European Society for Paediatric Gastroenterology. The need for nutrition support teamsin pediatric units: A commentary by the ESPGHAN committee on nutrition. J. Pediatr. Gastroenterol. Nutr. 2005;41:8–11. doi:10.1097/01.MPG.0000163735.92142.87.

[3] Teixeira A.F., Viana K.D. Nutritional screening in hospitalized pediatric patients: A systematic review. J. Pediatr.2016;92:343–352. doi: 10.1016/j.jped.2015.08.011.

[4] Rinninella E., Ruggiero A., Maurizi P., Triarico S., Cintoni M., Mele M.C. Clinical tools to assess nutritional risk andmalnutrition in hospitalized children and adolescents. Eur. Rev. Med. Pharmacol. Sci. 2017;21:2690–2701.

研究设计

研究类型
Observational

入排标准

年龄范围
2.00 Year(s) 至 17.00 Year(s)(—)
性别
All

入选标准

  • Pediatric patients under the age of 2 -17 years who will be scheduled for surgery under GA will be included.
  • Parents or legal guardians of pediatric patients who provide written informed consent will be eligible for inclusion.
  • Patients with a baseline Glasgow Coma Scale score of 15/15 and an expected duration of surgery less then 60 minutes will be included.

排除标准

  • History suggestive of dementia (either listed in the medical record or reported by the patient) or any neurological disorder 2) History of any cerebral surgeries 3) History suggestive of psychiatric disease like schizophrenia, dementia, anxiety or other disorder affecting cognition, mental dysfunction 4) Prescription of central nervous system active medication (eg: antidepressants, antipsychotics, sedatives).

研究者

发起方
Dr. Puneet Khanna
申办方类型
Other [self]
责任方
Principal Investigator
主要研究者

Dr Puneet Khanna

All India Institute of Medical Sciences

研究点 (1)

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