To compare the effect of the drugs, midazolam (in low dose) and midazolam with fentanyl, on muscle movement caused by another drug, etomidate, when it is used for giving anaesthesia before surgery.
Not Applicable
- Conditions
- Health Condition 1: Y658- Other specified misadventures during surgical and medical care
- Registration Number
- CTRI/2019/05/018920
- Lead Sponsor
- Department of Anesthesiology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
American Society of Anesthesiology physical status I and II adult patients undergoing elective surgical procedures under general anaesthesia
Exclusion Criteria
Patients with
1. History of any neurological disease
2. Adrenal cortical dysfunction
3. History of allergy to study drugs
4. Those having received any sedative within previous 24 hours
5. Pregnant or lactating women
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Occurrence of myoclonic movements after etomidate injection.Timepoint: Upto 90 seconds after etomidate injection
- Secondary Outcome Measures
Name Time Method To study the effect of pretreatment with low dose midazolam with fentanyl and midazolam alone on heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure and oxygen saturationTimepoint: After test drug administration and then every minute for 5 minutes