A study of incidence, clinical profile and etiology of congenital hypothyroidism in a tertiary care hospital.
Overview
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Not applicable
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- To study incidence, clinical profile and etiology of congenital hypothyroidism in term newborns and clinical profile, etiology in children aged less than 5 years in whom congenital hypothyroidism is diagnosed at an age ≤ 1 year
Overview
Brief Summary
In subgroup 1 , all term newborns admitted under neonatology will be screened for congenital hypothyroidism after 48 - 72 hours of life (standard treatment) (TSH based screening) .Diagnosis of congenital hypothyroidism will be entertained as per ISPAE 2018 criteria. After diagnosis is confirmed : USG neck , Tc 99 thyroid scan, hearing test will be done as per standard of care. Clinical profile of such newborns will be documented . In subgroup 2 , children aged < 5 years who are already diagnosed to have congenital hypothyroidism coming up for follow up will be studied. Patients will be included in the study only if their thyroid function test at the time of diagnosis satisfy ISPAE 2018 diagnostic criteria . Detailed history, age ,investigations at the time of diagnosis , type of congenital hypothyroidism , dose of thyroxine , growth ,development and other relevant information will be documented.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 1.00 Day(s) to 5.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •2 subgroups: Subgroup 1: All term newborns admitted under Department of Neonatology undergoing NBS for Congenital Hypothyroidism Subgroup 2: Children aged less than 5 years diagnosed with Congenital Hypothyroidism at an age ≤ 1 year at the Department of Paediatrics , Kasturba Medical College, Manipal.
Exclusion Criteria
- •Children whose parents deny consent.
Outcomes
Primary Outcomes
To study incidence, clinical profile and etiology of congenital hypothyroidism in term newborns and clinical profile, etiology in children aged less than 5 years in whom congenital hypothyroidism is diagnosed at an age ≤ 1 year
Time Frame: At admission (48 -72 hours of life) for term newborns in subgroup 1 and at follow up clinical visit in subgroup 2
Secondary Outcomes
- Not applicable(Not applicable)
Investigators
Priyanka P
Kasturba Medical College,MAHE,Manipal-576104