Electroencephalogramic changes during remimazolam general anesthesia: the relationship between estimated effect-site concentrations and the characteristics of electroencephalogramic changes at unconscious and conscious states
Not Applicable
- Conditions
- Of patients who are undergoing elective breast surgery, participants are included if they have both of the following: 1) American Society of Anesthesiologist (ASA) physical status (PS) classification 1 or 2 2) Capability of providing written consent before participation to this study
- Registration Number
- JPRN-UMIN000040606
- Lead Sponsor
- Showa University Department of Anesthesiology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- Female
- Target Recruitment
- 40
Inclusion Criteria
Not provided
Exclusion Criteria
Participants are excluded if they have any of the following: 1) Contraindications listed on the package insert of remimazolam (hypersensitivity to any of the components of remimazolam, acute closed angle glaucoma, myasthenia gravis, shock, coma, or acute alcoholic poisoning accompanying suppressed vital signs) 2) Contraindication to benzodiazepine 3) History of long-term administration of benzodiazepine 4) Contraindication to fentanyl, remifentanyl, or rocuronium 5) Severe liver dysfunction, renal dysfunction, or heart disease that may affect the safety assessment of remimazolam 6) ASA PS>=3 7) Others that the investigators consider to be inappropriate for a participant of the study
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The relationship between estimated effect-site remimazolam concentrations, and frontal EEG changes during general anesthetic induction, maintenance , and emergence phases, respectively.
- Secondary Outcome Measures
Name Time Method The relationship between estimated effect-site remimazolam concentrations, and Patient State Index (PSI) during induction , maintenance , and emergence phases, respectively. The trend in EEG frequency change depending on age. The relationship between age and the time from the end of remimazolam administration to recovery of consciousness.