Use of biologics like Platelet rich plasma in osteoarthritis of knee for cartilage regeneration

Phase 3

Not yet recruiting

• Conditions: Diseases of the musculoskeletal system and connective tissue, (2) ICD-10 Condition: M171||Unilateral primary osteoarthritisof knee,

• Registration Number: CTRI/2023/07/055142
• Lead Sponsor: JAWAHARLAL NEHRU MEDICAL COLLEGE

Brief Summary

Osteoarthritis is the most common cause of disability in the older population.It is due to the wear of the cartilage. Direct infiltrate of Platelet rich plasma in the normal or near normal cartilage should trigger cartilage regeneration leading to filling up of the cartilage defect/improving the quality of remaining cartilage.Proximal fibular osteotomy should deload the medial compartment and further assist the prevention of cartilage regeneration by indirect prevention.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-07-20
• Last Update Posted: 2023-12-07

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• 1- Patients OA knee.
• Grade II and III 2- Radiological evidence of medial compartment involvement. 3- Primary OA knee patients. 4- Patients who are willing to take part in study after informed consent.

Exclusion Criteria

• 1-Post traumatic knee stifness 2-History of infective joint disease.
• 3-Patients with history of previous surgeries of knee.
• 4-Co-morbid/pathology of ipsilateral hip/foot joint pathology 5-Any other defect of ipsilateral limb like shortening etc.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Biomechanical correction with biologics (PRP) can lead to cartilage regeneration	at 0 , 3 , 12 , 24 weeks and 9 months

Secondary Outcome Measures

Name	Time	Method
Correction of varus deformity	Correction of varus deformity at 0, 6 , 12 , 24 weeks and 6 and 9 months

Trial Locations

Locations (1)

Acharya Vinoba Bhave Rural Hospital; 🇮🇳 Wardha, MAHARASHTRA, India

Acharya Vinoba Bhave Rural Hospital

🇮🇳Wardha, MAHARASHTRA, India

Dr Aditya Pundkar

Principal investigator

9975170898

draditya.pundkar@gmail.com