THE EFFECT OF IBUPROFEN AND PARACETAMOL ON REACTIVE OXYGEN SPECIES (ROS) IN LEUKOCYTES. - THE EFFECT OF IBUPROFEN AND PARACETAMOL ON REACTIVE OXYGEN SPECIES (ROS) IN LEUKOCYTES.
- Conditions
- Radical oxygen activity in leukocytes.
- Registration Number
- EUCTR2009-009036-77-NO
- Lead Sponsor
- Section of dental pharmacology and pharmacotherapy, ICO, University of Oslo
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Authorised-recruitment may be ongoing or finished
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
Fasting, healthy, adult volunteers, ASA classification I (age 18-35 years) of both genders taking no NSAID on a regular basis.
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range
Exclusion Criteria
Not provided
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: The aim primary of this study is to investigate the capacity of leukocytes to respond with ROS synthesis upon a defined in vitro stimulus, PMA, after exposure to ibuprofen and paracetamol in vivo.;Secondary Objective: A second aim is to examine if platelet activation status is affected by the respective drugs.;Primary end point(s): ROS-activity i leukocytes
- Secondary Outcome Measures
Name Time Method