Retrospective Review of Indications and Results of Brain MRI With Anesthesia/Sedation in Children Less Than Three Years of Age
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Seizures
- Sponsor
- Baylor College of Medicine
- Enrollment
- 561
- Locations
- 1
- Primary Endpoint
- Etiologic diagnosis obtained from MRI brain
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
The investigators aim to identify the frequency with which an elective brain MRI yields and etiologic diagnosis to explain its indication. The protocol includes children undergoing elective brain MRI with anesthesia prior to their third birthday.
Detailed Description
On December 14, 2016 the FDA issued a warning regarding elective anesthetics in children under three years of age. While a single, short exposure to general anesthesia may not have negative effects on behavior or learning, repeated or prolonged anesthetics may affect brain development. To that end, minimizing exposure to elective general anesthetics if procedures are not clearly indicated in young children appeals to reason.
Investigators
Jamie Sinton
Assistant Professor
Baylor College of Medicine
Eligibility Criteria
Inclusion Criteria
- •Male or female aged 0-36 months who received anesthesia (volatile gas anesthesia) or IV sedation (propofol, dexmedetomidine, barbiturates, benzodiazepines, or other agents) for brain MRI
Exclusion Criteria
- •MRI without sedation, brain MRI plus additional MRI imaging, i.e. spine, heart, etc., sedated MRI by a member of other department besides Anesthesiology.
Outcomes
Primary Outcomes
Etiologic diagnosis obtained from MRI brain
Time Frame: 1 year
Determine the incidence of brain MRI abnormality that led to etiological explanation of developmental delay, autism or seizure.
Secondary Outcomes
- Incidence of repeat MRI(1 year)
- Quantify anesthetic exposure(1 year)