Breathe Easy Early Study (BEES): A randomised control study assessing the efficacy of early intervention with humidified high flow nasal cannula in the emergency department-Optimising outcomes in the Golden Hour of Respiratory failure.

Phase 2

• Conditions: Respiratory illnesses; Chronic respiratory conditions; Congestive Heart Failure; Acute Respiratory illnesses; Cardiovascular - Other cardiovascular diseases; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12616000587404
• Lead Sponsor: Ipswich Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-05-06
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 268

Inclusion Criteria

18 years and over
Symptomatic breathlessness- increased respiratory rate > 25 breaths per min and observed increased work of breathing.
Patients requiring oxygen supplementation to maintain Sp02 > 94% for acutely unwell patient OR 88% to 92% for those at risk of hypercapnic respiratory failure (in line with recruiting site hospital).

Exclusion Criteria

Recent ENT surgery
Epistaxis/ nasal trauma/ sinus problems
Altered level of consciousness
Pregnancy
Non invasive ventilation at point of triage
Pneumothorax/chest trauma
History of trauma eg. post fall
Falling GCS or GCS <9

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary outcome will be the proportion of patients who experience relief of dyspnea. This will be defined as a reduction of 20 points on a 100mm visual analogue scale (VAS), reduction in heart and respiratory rate prior to discharge from ED. The proportion of patients who achieve dyspnea relief in each group will be reported and the differences between each group (with a 95% confidence interval of the difference) will be reported.[Baseline visual analogue scale( VAS) - Included as part of the initial assessment (prior to any or just as initial intervention takes place), then will continue 30minutely for 90minutes whilst in the ED. If patient is admitted to the ward then hourly-4hrly depending on the patients clinical condition or wards protocol.]