Influence of individual genetic determination of the BDNF Val66Met polymorphism on plasticity-related sensorimotor recovery after ischemic stroke

Not Applicable

• Conditions: I63; Cerebral infarction

• Registration Number: DRKS00003515
• Lead Sponsor: eurologischen Klinik und PoliklinikBG-Universitätsklinikum BergmannsheilRuhr-Universität Bochum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-01-31
• Study Completion: 2013-12-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

Aged between 40 and 70 years;

Right-handedness before the infarction according to the Einburgh Inventory of Handedness;

Ischemic infarct (cortical/subcortical) in the coverage area of the middle cerebral artery, according to cranial CT or MRI;

Unilateral impairment of sensorimotor performance of upper extremities, i.e. an easy-to-moderate hemiparesis: Grade 3-5 according to MRC;

Ability to conduct subtest 1 and 2 of the Jebsen-Taylor Hand Function Test

Exclusion Criteria

Lack of knowledge of German language (subjective assessment of the experimenter);
Cognitive impairment in accordance DemTect (score <10; without the task 2 convert numbers);
Taking CNS-active drugs of any kind;
Residual symptoms of previous neurological diseases (including stroke, lesions, polyneuropathy);
Psychiatric disorders that might influence therapy;
Pacemaker (safety criterion for the electrical stimulation);
Increased muscle tone in the proximal or distal arm muscles (> 1 + according to MAS);
Excessive hand tremor (= 1 in subitem 20; 21 of the UPDRS);
Absolute loss of sensorimotor performance of upper extremities (hemi- or paraplegia) and severe paresis (MRC grade 0-2; inability to perform subtest 1 and 2 of the Jebsen-Taylor Hand Function Test);
Aphasia, preventing an informed consent;
Neglect;
Apraxia;
Perception threshold of electric stimulation of 20 mA / channel

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Assessment of sensorimotor performance before and after 10 days of standard rehabilitation (control group).<br>Assessment of sensorimotor performance before and after 10 days of standard rehabilitation and additional daily electrical hand stimulation (control group)

Secondary Outcome Measures

Name	Time	Method
Evaluation of the suitability for daily use of the electrical stimulation method (application, comfort). Evaluation of the subjective experience of the patient (performance improvements).