Vasa studie.
- Conditions
- Patient from the outpatient clinic of Cardiology and Vascular Medicine with hypertension, diabetes mellitus, hypercholesterolemia, smoking, and/or a family history of cardiovascular disease
- Registration Number
- NL-OMON26282
- Lead Sponsor
- Erasmus MC
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 200
Inclusion Criteria
1. >18 years of age;
2. Presence of cardiac risk factors.
Exclusion Criteria
1. Unstable clinical symptoms;
2. Contraindications for contrast-enhanced ultrasound.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. A quantification method for vasa vasorum imaging using contrast-enhanced ultrasound of the carotid arteries will be developed, using physical ultrasound parameters;<br /><br>2. The vessel wall thickness (intima-media thickness) and vasa vasorum will be evaluated in patients with hypertension, diabetes mellitus, hypercholesterolemia, smoking, and/or a family history of cardiovascular disease to assess the incidence and prevalence of an increased density of the vasa vasorum network;<br /><br>3. A follow-up study will be performed to evaluate a relation between ultrasound parameters and prognosis.<br>
- Secondary Outcome Measures
Name Time Method 1. Side-effects will be registered;<br /><br>2. Image quality and interpretability will be evaluated.<br><br /><br /><br>Other study parameters:<br /><br>1. Demographics, gender, age, body-mass index;<br /><br>2. Cardiovascular risk profile (SCORE).<br>