The effect of low FODMAP (Fermentable, Oligo-, Di-, Mono-saccharides And Polyols) diet with and without gluten on clinical outcomes and quality of life in patients with irritable bowel syndrome

Shahid Beheshti University of Medical Sciences0 个研究点目标入组 50 人开始时间: 待定最近更新: 2020年6月15日

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试验速览

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•Age 18 to 65 years
•Patients with irritable bowel syndrome, according to a gastroenterologist diagnosed according to ROME IV criteria (having at least one day a week over the past 3 months for at least two of the following: 1- related to Defecation; 2- related to the frequency of defecation, 3- related to changes in stool shape and consistency, and no pathological findings in gastrointestinal
•Body Mass Index in range (18-25)
•Lack of any organic intestinal disease ( diagnosed by last 5 years ago colonoscopy) and intestinal infection (diagnosed by stool culture)
•Lack of medical history of chronic gasrtointestinal and colorectal disease
•Lack of any major bowel surgery
•Absence of regular use of laxatives or anti diarreheal drugs
•No chronic use of corticosteroids and immunosuppressants
•No usage of drugs that modifying the digestive motility such as metoclopramide, cisapride, diphenoxylates
•No usage of drugs that increased bleeding of intestinal mucosa such as aspirin, warfarin and heparin
•Lack of pregnancy or breastfeeding?athlete or hospitalization
•Absence of severe mental or behavioral disorder
•Absence of nicotine and its derivatives use in the last 6 months
•No usage of NSAIDs and aspirin in last week (effect on gut permeability)

•consumption of artificial sweeteners(effet on intestinal permeability) 2 days before entering the study
•not agree to entering the study

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