JPRN-jRCTs031230644
Recruiting
未知
Investigation for efficacy and safety of mGlu2/3R PET ligand [18F] EST-604
Tagai Kenji0 sites36 target enrollmentFebruary 19, 2024
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Tagai Kenji
- Enrollment
- 36
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •(A) Brain kinetic evaluation
- •Healthy adults (10 subjects)
- •Those who apply voluntarily and are judged by the Principal Investigator, etc. to be capable of understanding the contents of the explanatory documents.
- •MCI patients (10 subjects ) AD patients (10 subjects)
- •1\. patients who can be accompanied on the day of their participation in the study at the QST by a person who can serve as a surrogate if the patient is unable to give his/her own consent.
- •2\. MCI patients: Patients who meet the diagnostic criteria for mild cognitive impairment due to Alzheimer's disease in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM\-5\).
- •3\. AD patients: Those who meet the diagnostic criteria of dementia due to Alzheimer's disease among the diagnostic criteria of DSM\-5\.
- •(B) Whole body kinetic evaluation
- •Healthy adults (6 subjects)
- •Those who apply voluntarily and are judged by the Principal Investigator, etc. to be capable of understanding the contents of the explanatory documents.
Exclusion Criteria
- •1\.Individuals with a history or current presence of organic brain disorders (such as consciousness disorders, head injuries requiring hospitalization, obvious cerebral infarction or hemorrhage).
- •2\.Individuals with substance\-related disorders (such as drug dependency).
- •3\.Those with serious complications of diseases, or those with a history of such conditions, deemed inappropriate as subjects for this study by the research physician.
- •4\.Individuals with magnetic metals in the body (including tattoos or permanent makeup, pacemakers, etc.) (for Brain kinetic evaluation only).
- •5\.Individuals with a strong fear of enclosed spaces.
- •6\.Those who are pregnant, might be pregnant, or are breastfeeding.
- •7\.Individuals allergic to local anesthetics and anticoagulants (for Brain kinetic evaluation only).
- •8\.Individuals currently taking anticoagulant medications (for Brain kinetic evaluation only).
- •9\.Others deemed inappropriate as subjects by the research physician.
Outcomes
Primary Outcomes
Not specified
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