Growth in adolescence: Potential interventions to improve growth and health and reduce the risks of future non-communicable disease
Completed
- Conditions
- 1. Stunting 2. Increased risk of future non communicable disease (NCD)Nutritional, Metabolic, Endocrine
- Registration Number
- ISRCTN43582765
- Lead Sponsor
- ondon School of Hygiene and Tropical Medicine (LSHTM)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 780
Inclusion Criteria
1. Adolescents aged 10-19 years
2. Both males and females
3. Living in Karonga district or Lilongwe Area 25
Exclusion Criteria
1. Visiting adolescents who do not live in the catchment area
2. Adolescents who do not have full consent to participate in the study
3. Adolescents with a disability that means a height measure cannot be obtained
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Prevalence of stunting defined as height-for-age z score <-2 based on WHO 2007 Growth Standards, in adolescents aged 10-19 years in study communities in Karonga and Area 25 of Lilongwe <br>2. Views of adolescents on design of a future intervention assessed through qualitative interviews <br>3. Baseline means and standard deviations for:<br>3.1. Steps per day measured with Actilife accelerometers worn for 48 hours<br>3.2. Key CANTAB (cognitive function) outcomes, as dictated by the manufacturers, from a battery of 6 tests: Motor Screening Task (MOT), Paired Associates Learning (PAL), Pattern Recognition Memory (PRM), Reaction Time (RTI), Emotion Recognition Task (ERT) and Spatial Span (SSP)<br>3.3. Resistance, Reactance, Impedance Index and Phase angle measured by BIA device<br>3.4. Hand grip strength measured as the best of 3 attempts on each hand
- Secondary Outcome Measures
Name Time Method 1. Intra-cluster correlation coefficient for HAZ (height-for-age z-score),steps per day, CANTAB outcomes, BIA outcomes and hand grip strength.<br>2. Views of parents, community leaders and relevant professionals on the design of a future intervention assessed though qualitative interviews <br>3. Risk factors for stunting, poor health and NCDs in this population including:<br>3.1. Blood pressure <br>3.2. Nutritional intake measured using FAO 24 hour food recall method<br>3.3. Waist/hip circumference ratio<br>3.4. Sitting height<br>3.5. Behaviour and hygiene factors measured using standard questions from WHO Global school-based student health survey (GSHS)<br>3.6. Socioeconomic status calculated using principal components analysis (PCA) of standard asset questions from the Malawi Demographic Health Survey (DHS)<br>4. Mean difference between main outcomes (CANTAB outcomes, steps per day, BIA outcomes and handgrip strength) between stunted and non-stunted individuals