Study on the effect of the interaction of short-term combined use of NSAIDS with diuretics and/or RAAS-inhibitor in post-operative elective orthopedic patients
Phase 4
Recruiting
- Conditions
- heart failurehypertension100192801002321310038430
- Registration Number
- NL-OMON31513
- Lead Sponsor
- Deventer Ziekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 124
Inclusion Criteria
elective knee- or hipreplacement
use of RAAS-inhibitors and diuretics
Exclusion Criteria
hipfracture with replacement
revision of the knee or hip
hospitalisation <4 days
nephrotoxic drugs
other medication use with possible NSAID's interactions
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>- systolic bloodpressure<br /><br>- diastolic bloodpressure<br /><br>- glomulair filtration rate</p><br>
- Secondary Outcome Measures
Name Time Method <p>- oedema<br /><br>- serum creatinine<br /><br>- serum Na+<br /><br>- serum K+<br /><br>- consult cardiology/internal<br /><br>- dose reduction/escalation diuretics/RAAS-inhibitor</p><br>