NCT01212523已完成4 期
Randomised Cross-over Pilot Study to Determine the Effects of Isoflurane and Propofol on Pulmonary Vascular Resistance in Children With Pulmonary Hypertension.
University Hospitals Bristol and Weston NHS Foundation Trust2 个研究点 分布在 1 个国家目标入组 10 人开始时间: 2009年11月1日最近更新:
适应症
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- The primary endpoint is the percentage change in PVR under isoflurane anaesthesia compared with propofol anaesthesia.
研究概览
简要总结
The investigators hypothesize that there is no difference between the effects of isoflurane and propofol anaesthesia on pulmonary vascular resistance (PVR).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Diagnostic
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 3 Months 至 16 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All children between 3 months and 16 years of age with pulmonary arterial hypertension undergoing a PVR study.
排除标准
- •Children with a known adverse reaction to one of the study drugs eg malignant hyperpyrexia or a disorder of fatty acid oxidation.
结局指标
主要结局
The primary endpoint is the percentage change in PVR under isoflurane anaesthesia compared with propofol anaesthesia.
时间窗: 2 hours
次要结局
- The secondary endpoints are the percentage change in mean pulomanry artery pressure (PAP), systemic vascular resistance (SVR) and mean arterial pressure (MAP).(2 hours)
研究者
Michelle White
Consultant in Paediatric Anaesthesia and Critical Care
University Hospitals Bristol and Weston NHS Foundation Trust
研究点 (2)
Loading locations...
相似试验
已完成
不适用
Randomized Crossover study to compare the effects of trelagliptin and omarigliptin on type 2 diabetes mellitus patients who were formerly treated with other DPP-4 inhibitorsJPRN-UMIN000029743Haga Diabetes Clinic100
招募中
不适用
Prospective randomized study to compare the influence of two different intraoperative gas pressure maximum values ??( 8 and 15 mmHg ) during laparoscopic surgery in terms of postoperative pain and pain medication consumptioD25.9N80Leiomyoma of uterus, unspecifiedEndometriosisDRKS00009382niversitätsfrauenklinik Homburg60
招募中
不适用
The effects of washing-without-water compared to the traditional bed bath with water and soap on emotional and physical comfort of the person being bathed in bed and on physical demands for the person providing the bed bath.Emotional comfort, physical comfort, physical demands for nurses, bed bathNL-OMON27573Maastricht University200
已完成
4 期
The pharmacokinetics of intranasal droperidol in healthy volunteers.Pharmacokinetics of intranasal drug delivery in healthy human volunteers.Other - Research that is not of generic health relevance and not applicable to specific health categories listed aboveACTRN12614000514606Monash Health7
招募中
2 期
Clinical study to see the effect of Ayurvedic drugs in the management of Allergic Rhinitis.â??CTRI/2020/06/025895ational Institute Of Ayurveda Jaipur