Effects of Propofol and Isoflurane on Pulmonary Vascular Resistance

Phase 4

Completed

• Conditions: Hypertension, Pulmonary

• Registration Number: NCT01212523
• Lead Sponsor: University Hospitals Bristol and Weston NHS Foundation Trust

Brief Summary

The investigators hypothesize that there is no difference between the effects of isoflurane and propofol anaesthesia on pulmonary vascular resistance (PVR).

Detailed Description

Not available

Study Timeline

• Study Start: 2009-11
• Study First Submitted: 2009-11-04
• Study First Submitted QC: 2010-09-29
• Study First Posted: 2010-09-30
• Status Verified: 2011-12
• Primary Completion: 2011-12
• Study Completion: 2011-12
• Last Update Submitted: 2011-12-14
• Last Update Posted: 2011-12-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• All children between 3 months and 16 years of age with pulmonary arterial hypertension undergoing a PVR study.

Exclusion Criteria

• Children with a known adverse reaction to one of the study drugs eg malignant hyperpyrexia or a disorder of fatty acid oxidation.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
The primary endpoint is the percentage change in PVR under isoflurane anaesthesia compared with propofol anaesthesia.	2 hours

Secondary Outcome Measures

Name	Time	Method
The secondary endpoints are the percentage change in mean pulomanry artery pressure (PAP), systemic vascular resistance (SVR) and mean arterial pressure (MAP).	2 hours

Trial Locations

Locations (1)

UH bristol NHS Trust; 🇬🇧 Bristol, United Kingdom