An observational study into the occurrence of panic attacks after inhalation of 65% oxygen and 35% carbon dioxide.
Recruiting
- Conditions
- Panic disorders
- Registration Number
- NL-OMON26851
- Lead Sponsor
- CHDR
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
•Informed consent in writing.
•Healthy male or female aged between 18 and 55 years (inclusive) at screening.
Exclusion Criteria
•Current or past history of any psychiatric disorder as classified according to DSM-IV or DSM 5.
•Current or past history of alcohol or any substance abuse or dependence disorder within the past 12 months.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To investigate the difference in response between single and double vital capacity 35% CO2/65% O2 in terms of the occurrence of PA’s in healthy subjects as measured with the Panic Symptoms List-IV (PSL-IV) and VAS subjective anxiety and fear.
- Secondary Outcome Measures
Name Time Method •explore whether the occurrence of PA’s on a single vital capacity inhalation 35% CO2/65% O2 predicts the occurrence of PA’s on a double vital capacity inhalation 35% CO2/65% O2.<br /><br>•explore the temporal stability of the occurrence of 35% CO2/65% O2-induced PA’s in subjects who develop PA’s on a single vital capacity inhalation and subsequently receive a double vital capacity inhalation.<br /><br>•explore the effects of single and double breath 35% CO2/65% O2 on heart rate, blood pressure, respiratory rate.<br /><br>•explore differences in sensitivity to 35% CO2/65% O2 between male and female subjects<br>