Behandeleffecten van een kortdurende intensieve behandeling (8 dagen) van obsessief compulsieve stoornis en paniekstoornis bij patienten die nonresponder zijn op een eerdere cognitieve gedragstherapeutische behandeling.
- Conditions
- Obsessive-compulsive disorderPanic disorderIntensive CBTnonrespondersobsessieve compulsieve stoornisPaniekstoornisintensieve cognitieve gedragstherapie
- Registration Number
- NL-OMON29480
- Lead Sponsor
- Overwaal Pro Persona
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Other
- Sex
- Not specified
- Target Recruitment
- 20
A primary diagnosis of panic disorder or obsessive-compulsive disorder according to the DSM IV(assessed with the MINI, Sheehan et al 1998; Overbeek et al.,1999).
Age between 18-70.
Patients have had an adequate CBT treatment. An adequate CBT treatment is defined as CBT with exposure and response prevention with most weekly sessions for at least a period of 12 weeks for panic disorder and 20 weeks for OCD.
Patients still have significant symptoms and did not experience a significant change in symptoms. Significant symptoms are defined as a score of at least 11 on the Panic Disorder Severity Scale (PDSS; Shear et al., 1992) or a score of at least 10 when the diagnosis is panic disorder without agoraphobia, and a score of at least 4 on the Clinical Global Impression (CGI; Guy, 1976). Significant symptoms for OCD are defined as a score of at least 16 on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS; Goodman, 1989) or a score of at least 10 when the diagnosis is primary obsessions, and a score of at least 4 on the Clinical Global Impression (CGI; Guy, 1976).
Concurrent use of antidepressants is allowed, doses have to be kept constant during the study. PD patients have to be on a constant dose 2 months before the study, OCD patient have to be on a constant dose 3 months before the study.
Concurrent use of benzodiazepines is allowed, when kept on a constant dose and taken at fixed times and not exceed the equivalence of 30 mg oxazepam.
Severe, unstable mental disorder like depressive disorder or risk of suicide, psychotic disorder or bipolar disorder (assessed with the MINI);
Comorbid diagnosis of hoarding;
Cognitive malfunctions
Mental retardation;
Patient is not able to focus on treatment for 2 weeks because of social problems;
Inability to read, write and speak in the Dutch language;
Patient will not be able to taper off drug or alcohol use before treatment.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method OCD or panic disorder symptoms
- Secondary Outcome Measures
Name Time Method Depressive symptoms, general functionig and quality of life.