Comparative Evaluation of Periodontal therapy on Salivary Alkaline Phosphatase and Acid Phosphatase level in Non-smoker and Smoker with Chronic Periodontitis:A Biochemical Study
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- The primary outcomes were changes in alkaline phosphatase (ALP) and acid phosphatase (ACP) levels in saliva following periodontal therapy along with gingival index,plaque index,clinical attachment level and probing depth and comparing before and after result.
Study Overview
Brief Summary
This prospective interventional study aimed to evaluate and compare the effects of non surgical periodontal therapy on clinical and biochemical parameters in individuals with chronic periodontitis stratified by smoking status A total of 60 participants aged 30 50 years were categorized into three groups non smokers Group A former smokers Group B and current smokers Group C Clinical parameters plaque index gingival index probing pocket depth and clinical attachment level were recorded at baseline and at 4 weeks post therapy Unstimulated saliva samples were collected at baseline 15 days and 4 weeks to measure levels of alkaline phosphatase and acid phosphatase using a semi autoanalyzer Non-surgical periodontal therapy will result in significant clinical and biochemical improvement in patients with chronic periodontitis however the extent of improvement will vary with smoking status with non-smokers exhibiting the most favorable response followed by former smokers and current smokers showing the least improvement
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Masking
- None
Eligibility Criteria
- Ages
- 30.00 Year(s) to 50.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Subjects unable to provide informed consent or comply with study protocol.
- •Patients with oral potentially malignant disorders and systemic illnesses such as diabetes, hypertension, thyroid or any known endocrine disorders, osteoarthritis, osteosarcoma, and renal failure were excluded.
- •Subjects with presence of fixed prosthesis and orthodontics appliances.
- •Patients presented with systemic disease, pregnant female, lactating or postmenopausal female.
Exclusion Criteria
- •Subjects unable to provide informed consent or comply with study protocol.
- •Patients with oral potentially malignant disorders and systemic illnesses such as diabetes, hypertension, thyroid or any known endocrine disorders, osteoarthritis, osteosarcoma, and renal failure were excluded.
- •Subjects with presence of fixed prosthesis and orthodontics appliances.
- •Patients presented with systemic disease, pregnant female, lactating or postmenopausal female.
Outcomes
Primary Outcomes
The primary outcomes were changes in alkaline phosphatase (ALP) and acid phosphatase (ACP) levels in saliva following periodontal therapy along with gingival index,plaque index,clinical attachment level and probing depth and comparing before and after result.
Time Frame: The primary outcomes were changes in alkaline phosphatase (ALP) and acid phosphatase (ACP) levels in saliva following periodontal therapy at baseline,15th day and 4week along with gingival index,plaque index,clinical attachment level and probing depth at baseline and 4weeks and comparing before and after result.
Secondary Outcomes
- Clinical periodontal parameters including probing pocket depth (PPD), clinical attachment level (CAL), plaque index (PI), & gingival index (GI) were assessed at baseline & at 4week post-treatment to evaluate the clinical effectiveness of periodontal therapy in current smoker,former smoker & non-smoker groups.(Clinical parameters including probing pocket depth (PPD), clinical attachment level (CAL), gingival index (GI), plaque index (PI) were recorded at baseline (Day 0) & at 4 weeks post-treatment, corresponding with the biochemical follow-up at baseline,15th day & 4week.)
Investigators
Dr Supriti Dutta
Nims Dental College and hospital,Jaipur