Imaging and Biomarkers of Hypoxia in Solid Tumors
- Conditions
- Neoplasms
- Interventions
- Registration Number
- NCT01123005
- Lead Sponsor
- Stanford University
- Brief Summary
Hypoxia, meaning a lack of oxygen, has been associated strongly with a wide range of human cancers. Hypoxia occurs when tumor growth exceeds the ability of blood vessels to supply the tumor with oxygenated blood. It is currently understood that hypoxic tumors are more aggressive. Current methods for measuring hypoxia include invasive procedures such as tissue biopsy, or insertion of an electrode into the tumor. EF5-PET may be a non-invasive way to measure tumor hypoxia.
- Detailed Description
To establish PET imaging with the tracer EF5 as an accurate and reliable method for measuring the oxygen content of a tumor and to establish the measurement of secreted markers in blood as an accurate and reliable method for measuring the oxygen content of a tumor.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 28
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SEQUENTIAL
- Arm && Interventions
Group Intervention Description Carbogen arm PET Scan - Carbogen arm EF5 - Carbogen arm Carbogen - DCA arm PET Scan - DCA arm EF5 - DCA arm Dichloroacetate -
- Primary Outcome Measures
Name Time Method 18F-EF5 uptake (tumor: blood ratio) before and after carbogen breathing for a subset of subjects. 1-5 days 18F-EF5 uptake (tumor: blood ratio) before and after administration of DCA for a subset of subjects. 1-5 days
- Secondary Outcome Measures
Name Time Method Levels of secreted hypoxia markers in plasma. 1-5 days Hypoxia gene and protein expression scores in patients undergoing biopsy or surgical resection. 1-5 days
Trial Locations
- Locations (1)
Stanford University School of Medicine
🇺🇸Stanford, California, United States