Long Term Follow-up of Bone Mineral Density in Hormone Treated Turner Syndrome
- Conditions
- Turner Syndrome
- Registration Number
- NCT00625001
- Lead Sponsor
- University of Aarhus
- Brief Summary
Turner Syndrome (TS) is associated with osteopenia and osteoporosis. Reduced bone mineral density (BMD) and increased risk of fractures are present in many younger and middle-aged women with TS. The objective is therefore to describe longitudinal changes in BMD in TS.
The study is an observational follow-up study. Examinations at baseline, after 5 and 10 years.
Bone mineral density is measured by dual energy x-ray absorptiometry (DEXA) and bone turnover by bone markers.
Main Outcome Measures: Bone mineral density (BMD; grams/ square centimetre) were measured at lumbar spine, hip and the non-dominant forearm.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 54
Inclusion Criteria
- Turner syndrome verified by karyotyping
Exclusion Criteria
- untreated hypothyroidism or hyperthyroidism
- present or past malignant diseases
- clinical liver disease
- treatment with drugs known to interfere with bone metabolism (e.g. glucocorticoids)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Bone Mineral Density in columna lumbalis, collum femoris and distal ulnae Bone mineral density (BMD; grams/ square centimetre) were measured at lumbar spine, hip and the non-dominant forearm. Evey 5 years
- Secondary Outcome Measures
Name Time Method