Long Term Follow-up of Bone Mineral Density in Hormone Treated Turner Syndrome
试验速览
- 阶段
- 不适用
- 入组人数
- 54
- 主要终点
- Bone Mineral Density in columna lumbalis, collum femoris and distal ulnae Bone mineral density (BMD; grams/ square centimetre) were measured at lumbar spine, hip and the non-dominant forearm.
研究概览
简要总结
Turner Syndrome (TS) is associated with osteopenia and osteoporosis. Reduced bone mineral density (BMD) and increased risk of fractures are present in many younger and middle-aged women with TS. The objective is therefore to describe longitudinal changes in BMD in TS.
The study is an observational follow-up study. Examinations at baseline, after 5 and 10 years.
Bone mineral density is measured by dual energy x-ray absorptiometry (DEXA) and bone turnover by bone markers.
Main Outcome Measures: Bone mineral density (BMD; grams/ square centimetre) were measured at lumbar spine, hip and the non-dominant forearm.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Turner syndrome verified by karyotyping
排除标准
- •untreated hypothyroidism or hyperthyroidism
- •present or past malignant diseases
- •clinical liver disease
- •treatment with drugs known to interfere with bone metabolism (e.g. glucocorticoids)
结局指标
主要结局
Bone Mineral Density in columna lumbalis, collum femoris and distal ulnae Bone mineral density (BMD; grams/ square centimetre) were measured at lumbar spine, hip and the non-dominant forearm.
时间窗: Evey 5 years
次要结局
未报告次要终点