The effect of vitamin D3 supplemenation in the prevention of Optic Neuritis conversion to Multiple Sclerosis in patients with low serum vitamin D status after one year follow up:a randomized double blind clinical trial.

Isfahan University of Medical Sciences0 个研究点目标入组 30 人开始时间: 待定最近更新: 2018年2月22日

适应症

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•Entry criteria were as follows: (1) optic neuritis male or female patients with age range of 20-40 years, (2) patients should not fulfill the 2005 revised Mc Donald Criteria for multiple sclerosis, at the time of inclusion in the study,(3) serum 25(OH)D level of less than 30ng/ml (4) seronegativity for anti-aquaporin4 and other autoimmune antibodies,
•Exclusion criteria are:(1) patients who have used vitamin D supplements at a level higher than 400IU/day before the onset of optic neuritis,(2)patients who used any medication that could influence the prognosis of optic neuritis (e.g. ß interferon) during the 12 months follow-up period,(3) women who were pregnant or breast feeding,(4) patients with kidney or liver dysfunction, (5)patients who demonstrated poor compliance with instructions to take vitamin D or placebo,or who failed to attend for follow- up visits, MRI scanning and vitamin D measurements during the study,(6)patients with a history of nephrolithiasis and(7) patients suffering from concurrent granulomatous diseases.

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